CONTRASTMEDIA

NIOSCAN (240/300/350)

(Non-Ionic Contrast Media)


IOHEXOL INJECTION USP

Low osmolar - Water Soluble - Iodinated Non - Ionic Contrast Media.

- Low osmolality.
- Low inhibition of enzyme activity.
- Low systemic toxicity.
- Low chemotoxicity.
- Low serum protein binding.
- Lesser influence on haemodynamic parameters.
- Little effect on coagulation.
- Low erythrocyte deformability.


NIOSCAN does not cross the intact blood brain barrier.

NIOSCAN does not lead to vacoulisation in cells of the proximal renal tuble.

NIOSCAN has minimal effects on blood pressure and heart rate.


COMPOSITION NIOSCAN 240 NIOSCAN 300 NIOSCAN 350
Iohexol 51.8% 64.7% 75.5%
Iodine Concentration 240 ml/ml 300 mg/ml 350 mg/ml
pH 7.2 + 0.4 7.0 + 0.4 7.0 + 0.4
Viscosity (mPa*s)
@37℃ 3.3 6.1 10.6
@20℃ 5.6 11.6 23.3
Osmolality (mOsm/g H2O)
@37℃ 0.51 0.64 0.78

DOSAGE AND ADMINISTRATION:

General:
The dosage veries depending on the types of examination, age, weight, cardiac output and general condition of the patient and the technique used. Usually the same iodine concentration and volume is used as with other iodinated X-Ray contrast media in current use. Adequate hydration should be assured before and after administration as for other contrast media. For intravenous, intra-arterial and intrathecal use and use in body cavities. The following dosages may serve as a guide.



INDICATIONS NIOSCAN 240 NIOSCAN 300 NIOSCAN 350
MYELOGRAPHY
Lumbar & thoracic myelography 8 - 12 ml ----- -----
Cervical myelography 6 - 10 ml 6 - 8 ml -----
CT Cisternography 4 - 12 ml ----- -----
ARTERIOGRAPHIES
Aortography ----- 30 - 40 ml/Inj. 40 - 60 ml/Inj.
Femoral ----- 30 - 50 ml/Inj. 30 - 50 ml/Inj.
Various ----- Depending on type of
examination		 -----
Selective Cerebral ----- 5 - 10 ml/Inj. -----
Arch Aortography ----- 30 - 40 ml/Inj. -----
CARDIOANGIOGRAPHY
Adults
--Left ventricle and aortic root Inj. ----- ----- 30 - 60 ml/Inj.
--Selective Coronary arteriography 4 - 8 ml/Inj. ----- -----
Children ----- Depending on examination
(max 8 ml / kg b.w.)		 Depending on examination
(max 8 ml / kg b.w.)
Digital Subtraction angiography (I.A.) 1 - 15 ml/Inj. 1 - 15 ml/Inj. -----
UROGRAPHY
Adults ----- 40 - 80 ml 40 - 80 ml
Children < 7 kg 4 ml / kg b.w. 3 ml / kg b.w. -----
Children > 7 kg 3 ml / kg b.w. (Max. 40 ml) 2 ml / kg b.w. (Max. 40 ml) -----
PHLEBOGRAPHY (Leg) 20 - 100 ml / leg 20 - 100 ml / leg -----
DIGITAL SUBTRACTION ANGIOGRAPHY (I.V.) ----- 20 - 60 ml/Inj. 20 - 60 ml/Inj.
COMPUTERISED TOMOGRAPHY
Adults 100 - 250 ml (Total Amit of
Iodine usually 30g-60g)		 100 - 200 ml (Total Amit of
Iodine usually 30g-60g)		 100 - 150 ml (Total Amit of
Iodine usually 30g-60g)
Children 2-3ml/kg b.w. (Upto 40ml) 1-3ml/kg b.w. (Upto 40ml) -----
BODY CAVITIES
ARTHROGRAPHY 5 - 20 ml 5 - 15 ml 5 - 10 ml
ERP / ERCP 20 - 50 ml ----- -----
HERNIOGRAPHY 50 ml ----- -----
HYSTEROSALPINGOGRAPHY 15 - 50 ml 15 - 25 ml -----
HYSTEROSALPINGOGRAPHY 15 - 50 ml 15 - 25 ml -----
SIALOGRAPHY 0.5 - 2 ml 0.5 - 2 ml -----
CT ENHANCEMENT (Oral use)
Adults 100 - 250 ml 100 - 200 ml 100 - 150 ml
Children 1-3ml/kg b.w. (Upto 40ml) 1-3ml/kg b.w. (Upto 40ml) -----
GASTROINTESTINAL STUDIES Depending on examination Depending on examination Depending on examination

CONTRAINDICATIONS:

Manifest thyrotoxicosis. History of serious reaction to IOHEXOL.


PRESENTATION:

NIOSCAN 240 : Single dose vial of 50 ml.
NIOSCAN 300 : Single dose vial of 10 ml, 20 ml, 40 ml, 50 ml and 100 ml.
NIOSCAN 350 : Single dose vial of 20 ml, 40 ml, 50 ml and 100 ml.


STORAGE:

Store at controlled room temperature 20℃ to 30℃.
Do not freeze. Protect from direct sunlight and secondary X-rays.
Inspect container for particulate matter before use. Discard unused portion.


NIOSCAN Brochure